Halbreich U, Rojansky N, Palter S
Department of Psychiatry, State University of New York at Buffalo 14215.
Fertil Steril. 1991 Dec;56(6):1066-9.
To assess whether the therapeutic effect of danazol on premenstrual syndromes (PMS) is associated with suppression of ovulation.
After 1 month on placebo, we administered 200 mg/d of danazol for 90 days to 24 women with dysphoric PMS. Symptoms during ovulatory cycles were compared with anovulatory periods.
Outpatient PMS program in a general hospital.
Twenty-four women who had dysphoric PMS and otherwise were physically and mentally healthy.
None (except the oral medication).
Prospective daily monitoring of symptoms with the Daily Rating Form, before, during, and after treatment.
Twenty of 23 anovulatory periods were symptom-free versus 6 of 32 ovulatory periods (chi 2 = 15.63, P = 0.0002).
The beneficial effect of danazol as treatment depends mostly on achieving an an-ovulatory state and elimination of hormonal cyclicity and not on the drug per se.
评估达那唑对经前综合征（PMS）的治疗效果是否与抑制排卵有关。
在服用安慰剂1个月后，我们给予24名患有烦躁型经前综合征的女性每天200毫克达那唑，持续90天。将排卵周期的症状与无排卵期进行比较。
一家综合医院的门诊经前综合征项目。
24名患有烦躁型经前综合征且身心健康的女性。
无（除口服药物外）。
在治疗前、治疗期间和治疗后，使用每日评分表对症状进行前瞻性每日监测。
23个无排卵期中有20个无症状，而32个排卵期中有6个无症状（卡方检验=15.63，P=0.0002）。
达那唑作为治疗药物的有益效果主要取决于达到无排卵状态并消除激素周期性变化，而非药物本身。
