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C反应蛋白、白细胞介素-1受体拮抗剂和脂联素与代谢综合征的关联

Association of C-reactive protein, interleukin-1 receptor antagonist and adiponectin with the metabolic syndrome.

作者信息

Saltevo Juha, Vanhala Mauno, Kautiainen Hannu, Kumpusalo Esko, Laakso Markku

机构信息

Department of Internal Medicine, Central Hospital of Middle Finland, 40620 Jyväskylä, Finland.

出版信息

Mediators Inflamm. 2007;2007:93573. doi: 10.1155/2007/93573.

DOI:10.1155/2007/93573
PMID:18288276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2222666/
Abstract

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

摘要

这项基于芬兰人群的研究，平均年龄为46岁，评估了高敏C反应蛋白（hs-CRP）、白细胞介素-1受体拮抗剂（IL-1Ra）和脂联素与美国国家胆固醇教育计划（NCEP）和国际糖尿病联盟（IDF）代谢综合征（MetS）定义之间的关联。与患有代谢综合征的受试者相比，未患代谢综合征的受试者脂联素水平较高，hs-CRP和IL-1Ra水平较低。如果根据IDF和NCEP标准均存在代谢综合征，与仅根据IDF或仅根据NCEP标准患有代谢综合征的受试者相比，体重指数（BMI）、腰围、甘油三酯、hs-CRP和IL-1Ra显著更高。根据两种定义，hs-CRP、IL-1Ra和脂联素与代谢综合征的组成成分数量呈线性相关。脂联素水平降低以及hs-CRP和IL-1Ra水平升高与代谢综合征的组成成分密切相关。根据两种标准均患有代谢综合征的个体在心血管危险因素方面有最不利的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/9526a7f280ef/MI2007-93573.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/0e5de34f3f7f/MI2007-93573.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/7f2413bec6f2/MI2007-93573.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/9526a7f280ef/MI2007-93573.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/0e5de34f3f7f/MI2007-93573.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/7f2413bec6f2/MI2007-93573.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9188/2222666/9526a7f280ef/MI2007-93573.003.jpg

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