Liu Ya-Li, Bi Hui, Chi Su-Min, Fan Rong, Wang Yue-Min, Ma Xin-Liang, Chen Yao-Ming, Luo Wen-Jing, Pei Jian-Ming, Chen Jing-Yuan
Department of Physiology, The Fourth Military Medical University, Xi'an 710032, Shaanxi, China.
Cytokine. 2007 Jan;37(1):14-21. doi: 10.1016/j.cyto.2007.02.009. Epub 2007 Apr 11.
The effect of compound nutrients on serum concentrations of the cytokines, such as interleukin (IL)-2, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in immobilization and cold water-immersion stressed rat were investigated. Oral (gavage) administration of compound nutrients was found to attenuate the acute and chronic immobilization and cold water-immersion stress-induced increase in serum IL-6 level and decrease in IL-2 level. Compound nutrients exerted different effects on TNF-alpha level in two different models studied, with reduced serum TNF-alpha level in acute stress, while no significant effect in chronic stress. These results suggested that compound nutrients might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders.
研究了复合营养素对制动和冷水浸泡应激大鼠血清中细胞因子浓度的影响，这些细胞因子包括白细胞介素（IL）-2、肿瘤坏死因子-α（TNF-α）和白细胞介素（IL）-6。发现口服（灌胃）复合营养素可减轻急性和慢性制动及冷水浸泡应激诱导的血清IL-6水平升高和IL-2水平降低。在两个不同的研究模型中，复合营养素对TNF-α水平产生了不同的影响，在急性应激中血清TNF-α水平降低，而在慢性应激中无显著影响。这些结果表明，复合营养素可能是应激相关疾病研究或治疗调节中的一个潜在候选物。
