Takehara K, Soma Y, Ishibashi Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Dermatologica. 1991;183(3):164-8. doi: 10.1159/000247662.
Fifty patients with the chief complaint of Raynaud's phenomenon (RP) presented at our scleroderma clinic from March to December 1990. Physical examination, routine laboratory tests (blood, urine and chest X-ray), determination of the pattern of RP, antinuclear antibody (ANA) tests and examination for nailfold bleeding were performed. Three patients were diagnosed as having systemic sclerosis sine scleroderma, 15 patients as having RP with positive anticentromere antibody and 6 patients as having an incomplete form of mixed connective tissue disease. Thus, a total of at least 24 patients out of 50 (48%) were shown to have a scleroderma spectrum disorder. A definite RP pattern (triphasic or biphasic and bilateral), positive ANA and positive nailfold bleeding were strongly correlated statistically, suggesting that these are simple useful findings for the early detection of scleroderma spectrum disorders in patients with RP. We expect that there are many undiagnosed patients with an early-stage scleroderma spectrum disorder in the general population.
1990年3月至12月，50例以雷诺现象（RP）为主诉的患者到我们的硬皮病诊所就诊。进行了体格检查、常规实验室检查（血液、尿液和胸部X线）、RP类型的测定、抗核抗体（ANA）检测以及甲襞出血检查。3例患者被诊断为无硬皮病的系统性硬化症，15例患者为抗着丝点抗体阳性的RP，6例患者为不完全型混合性结缔组织病。因此，50例患者中共有至少24例（48%）被证明患有硬皮病谱系疾病。明确的RP类型（三相或双相且双侧）、ANA阳性和甲襞出血阳性在统计学上密切相关，这表明这些是早期发现RP患者硬皮病谱系疾病的简单有用的发现。我们预计普通人群中有许多未被诊断的早期硬皮病谱系疾病患者。
