Vayssairat M, Baudot N, Gaitz J P
Laboratory of Microcirculation, Hôpital Rothschild, Paris, France.
J Am Acad Dermatol. 1995 May;32(5 Pt 1):747-9. doi: 10.1016/0190-9622(95)91453-6.
The frequency of incomplete connective tissue disease (ICTD) is unknown.
Our purpose was to determine the frequency of Raynaud's phenomenon (RP) and antinuclear antibodies (ANA) in patients without definite connective tissue disease.
A series of 165 consecutive patients with RP was investigated.
Fifty-one patients had primary RP; 60 had secondary RP; 54 patients were classified as having ICTD, 35 of whom had ANA and 19 of whom did not. Of the 35 patients who had ICTD with ANA, 29 were women and six were men. Their clinical findings were as follows: 17 had nonerosive arthritis, 14 had a nailfold capillary scleroderma pattern, 12 had puffy fingers, 10 had anticentromere antibodies, nine had sicca syndrome, seven had pernio, seven had esophagitis, six had fingertip ulceration, five had telangiectasia, four had malar eruption, four had myalgia, four had weight loss, four had exertional dyspnea, and three had photo-sensitivity. No patient exhibited life-threatening visceral complications or antitopoisomerase antibodies.
In this series ICTD was more frequent than definite connective tissue disease. Many patients with RP have ICTD that is sometimes chronic.
不完全性结缔组织病（ICTD）的发病率尚不清楚。
我们的目的是确定无明确结缔组织病患者中雷诺现象（RP）和抗核抗体（ANA）的发病率。
对连续的165例RP患者进行了调查。
51例患者为原发性RP；60例为继发性RP；54例患者被归类为患有ICTD，其中35例有ANA，19例没有。在35例患有ICTD且有ANA的患者中，29例为女性，6例为男性。他们的临床发现如下：17例有非侵蚀性关节炎，14例有甲襞毛细血管硬皮病样改变，12例有手指肿胀，10例有抗着丝点抗体，9例有干燥综合征，7例有冻疮，7例有食管炎，6例有指尖溃疡，5例有毛细血管扩张，4例有颧部皮疹，4例有肌痛，4例有体重减轻，4例有劳力性呼吸困难，3例有光敏性。没有患者出现危及生命的内脏并发症或抗拓扑异构酶抗体。
在本系列研究中，ICTD比明确的结缔组织病更常见。许多RP患者患有ICTD，有时呈慢性。
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