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Antinuclear antibodies in scleroderma, mixed connective tissue disease and "primary" Raynaud's phenomenon.

作者信息

Cruz M, Mejia G, Lavalle C, Cortes J J, Reyes P A

机构信息

Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico, D.F.

出版信息

Clin Rheumatol. 1988 Mar;7(1):80-6. doi: 10.1007/BF02284061.

DOI:10.1007/BF02284061
PMID:3261675
Abstract

The diversity of antibodies in patients with scleroderma, mixed connective tissue disease or "primary" Raynaud's phenomenon could be used as a laboratory aid in the clinical diagnosis. In serum samples of 75 patients we screened for antinuclear antibodies (HEp 2 cells), anti DNA, soluble nucleoprotein and extractable nuclear antigens (Sm, rRNP, U1-nRNP, SSA/Ro, SSB/La and Scl-70). Distinctive antinuclear antibodies pattern was identified in each group of patients. This immunologic profile is valuable for clinical diagnosis and the preferential association of certain autoantibodies with some diseases and not with others, suggest an antigen-driven stimulus for its production.

摘要

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Clin Rheumatol. 1988 Mar;7(1):80-6. doi: 10.1007/BF02284061.
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Rheumatology.

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MULTIPLE TELANGIECTASIA, RAYNAUD'S PHENOMENON, SCLERODACTYLY, AND SUBCUTANIOUS CALCINOSIS: A SYNDROME MIMICKING HEREDITARY HEMORRHAGIC TELANGIECTASIA.多发性毛细血管扩张、雷诺现象、指（趾）硬皮病和皮下钙质沉着：一种酷似遗传性出血性毛细血管扩张症的综合征。
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Studies on cytoplasmic ribonucleoprotein particles from the liver of the rat.对大鼠肝脏细胞质核糖核蛋白颗粒的研究。
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Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee.
风湿病学
Postgrad Med J. 1991 Feb;67(784):114-39. doi: 10.1136/pgmj.67.784.114.
4
Raynaud's phenomenon: its relevance to scleroderma.雷诺现象：其与硬皮病的相关性。
Ann Rheum Dis. 1991 Nov;50 Suppl 4(Suppl 4):839-45. doi: 10.1136/ard.50.suppl_4.839.
系统性硬化症（硬皮病）分类的初步标准。美国风湿病协会诊断与治疗标准委员会硬皮病标准小组委员会。
Arthritis Rheum. 1980 May;23(5):581-90. doi: 10.1002/art.1780230510.
4
A prospective study of Raynaud phenomenon and early connective tissue disease. A five-year report.雷诺现象与早期结缔组织病的前瞻性研究。一份五年报告。
Am J Med. 1982 Jun;72(6):883-8. doi: 10.1016/0002-9343(82)90846-4.
5
Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis.进行性系统性硬化症中抗核抗体与抗核仁抗体的关联。
Clin Exp Immunol. 1982 Apr;48(1):43-51.
6
Antinuclear antibodies in scleroderma.
Int J Dermatol. 1981 Nov;20(9):569-73. doi: 10.1111/j.1365-4362.1981.tb00835.x.
7
The CREST syndrome: a distinct serologic entity with anticentromere antibodies.CREST综合征：一种具有抗着丝点抗体的独特血清学实体。
Am J Med. 1980 Oct;69(4):520-6. doi: 10.1016/0002-9343(80)90462-3.
8
Mixed connective tissue disease: a subsequent evaluation of the original 25 patients.混合性结缔组织病：对最初25例患者的后续评估
Medicine (Baltimore). 1980 Jul;59(4):239-48.
9
A histologic evaluation of mixed connective tissue disease in childhood.儿童混合性结缔组织病的组织学评估
Am J Med. 1980 May;68(5):710-7. doi: 10.1016/0002-9343(80)90258-2.
10
Autoantibody to centromere (kinetochore) in scleroderma sera.硬皮病血清中的着丝粒（动粒）自身抗体。
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1627-31. doi: 10.1073/pnas.77.3.1627.