Bolognia J L
Yale University School of Medicine, New Haven, Conn.
Dermatologica. 1991;183(3):221-4. doi: 10.1159/000247675.
Pentamidine is one of two agents currently used to treat infections with Pneumocystis carinii. The intramuscular route of administration is associated with cutaneous side effects such as dermal necrosis, sterile abscesses and ulcer formation at the injection site, while urticaria may develop near the site of intravenous drug infusion. This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm. The area healed slowly over 7 weeks, but there was a residual loss of cutaneous sensation. In a review of the literature no report of a similar case was found.
喷他脒是目前用于治疗卡氏肺孢子虫感染的两种药物之一。肌内给药途径会伴有皮肤副作用，如注射部位出现皮肤坏死、无菌性脓肿和溃疡形成，而静脉药物输注部位附近可能会出现荨麻疹。本文报告了一名肾移植患者发生卡氏肺孢子虫肺炎，在静脉注射喷他脒外渗至左手和前臂软组织后出现化学性蜂窝织炎和溃疡。该区域在7周内缓慢愈合，但皮肤感觉仍有残留丧失。在文献综述中未发现类似病例的报告。
