酿酒酵母中dur基因座的结构分析：一个多功能基因的两个结构域。
Structural analysis of the dur loci in S. cerevisiae: two domains of a single multifunctional gene.
作者信息
Cooper T G, Lam C, Turoscy V
出版信息
Genetics. 1980 Mar;94(3):555-80. doi: 10.1093/genetics/94.3.555.
Abstract
In Saccharomyces cerevisiae, the degradation of urea to carbon dioxide and ammonia is catalyzed by urea carboxylase and allophanate hydrolase. The loci coding for these enzymes (dur1 and dur2) are very tightly linked on the right arm of chromosome II between pet11 and met8. Pleiotropic mutations that fail to complement mutations in either of the dur loci were found to be predominantly located in or near the dur2 locus. We interpret these data as suggesting that the two dur loci might in reality be domains of a single gene that codes for a multifunctional polypeptide. In view of this conclusion, we have renamed the dur loci as the dur1,2 locus.
摘要
在酿酒酵母中，尿素羧化酶和脲基甲酸水解酶催化尿素降解为二氧化碳和氨。编码这些酶的基因座（dur1和dur2）在位于pet11和met8之间的II号染色体右臂上紧密连锁。未能互补dur基因座中任一突变的多效性突变主要位于dur2基因座内或其附近。我们将这些数据解释为表明这两个dur基因座实际上可能是编码多功能多肽的单个基因的结构域。鉴于这一结论，我们已将dur基因座重新命名为dur1,2基因座。
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