T细胞急性淋巴细胞白血病中MYB癌基因的复制。
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
作者信息
Lahortiga Idoya, De Keersmaecker Kim, Van Vlierberghe Pieter, Graux Carlos, Cauwelier Barbara, Lambert Frederic, Mentens Nicole, Beverloo H Berna, Pieters Rob, Speleman Frank, Odero Maria D, Bauters Marijke, Froyen Guy, Marynen Peter, Vandenberghe Peter, Wlodarska Iwona, Meijerink Jules P P, Cools Jan
机构信息
Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.
出版信息
Nat Genet. 2007 May;39(5):593-5. doi: 10.1038/ng2025. Epub 2007 Apr 15.
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
我们在8.4%的T细胞急性淋巴细胞白血病（T-ALL）患者以及5种T-ALL细胞系中发现了MYB癌基因的重复。这种重复与MYB表达增加三倍相关，并且敲低MYB表达可启动T细胞分化。我们的结果确定MYB重复是一种致癌事件，并表明MYB可能是人类T-ALL的一个治疗靶点。
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