Maia Carlos Renato Moreira, Rohde Luis Augusto
Serviço de Psiquiatria da Infância e Adolescência, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brasil.
Braz J Psychiatry. 2007 Mar;29(1):72-9.
Anxiety disorders are very prevalent in children and adolescents, causing serious impairments. The pharmacological treatment for these disorders is not much investigated in children and adolescents. Thus, there is no consensus about its indication. The present study aims to check the efficacy and tolerability of drugs used for the treatment of anxiety disorders in children and adolescents in the context of evidence based medicine. A systematic literature review was carried out in the main databases. In addition, authors were contacted. We found seven studies classified as A or B according to criteria established by the Cochrane Collaboration. Findings suggest efficacy for selective serotonin reuptake inhibitors, insignificant or unfavorable results for benzodiazepines and imipramine. Some studies present methodological problems. Methodological improvements are needed in futures clinical trials.
焦虑症在儿童和青少年中非常普遍，会造成严重损害。针对这些病症的药物治疗在儿童和青少年中研究较少。因此，关于其适应症尚无共识。本研究旨在基于循证医学检验用于治疗儿童和青少年焦虑症的药物的疗效和耐受性。在主要数据库中进行了系统的文献综述。此外，还联系了作者。根据Cochrane协作网制定的标准，我们发现了七项被归类为A或B级的研究。研究结果表明选择性5-羟色胺再摄取抑制剂有效，而苯二氮䓬类药物和丙咪嗪的结果不显著或不利。一些研究存在方法学问题。未来的临床试验需要改进方法学。
