Roth Johannes, Bechtold Susanne, Borte Gudrun, Dressler Frank, Girschick Hermann J, Borte Michael
Department of Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany.
Eur J Pediatr. 2007 Aug;166(8):775-84. doi: 10.1007/s00431-007-0484-1. Epub 2007 Apr 14.
In all subgroups of juvenile idiopathic arthritis, a decrease in bone mass has been described in a high percentage of children. Recently, new pathogenetic concepts have identified muscle mass as the strongest predictor of bone mass and bone is now recognized as part of the musculoskeletal system. In addition, the sophisticated use of bone densitometry in pediatrics, including new measurement techniques, has provided the tools for a reliable assessment. A standardized diagnostic approach to the musculoskeletal system, including prophylaxis and therapy, is, therefore, mandatory in all children with JIA who do not achieve rapid remission. In this review, diagnostic and therapeutic options are being described and possibilities to incorporate them into clinical practice are suggested.
在所有幼年特发性关节炎亚组中，已有报道称高比例儿童存在骨量减少的情况。最近，新的发病机制概念已将肌肉量确定为骨量的最强预测指标，并且骨骼现在被认为是肌肉骨骼系统的一部分。此外，儿科中骨密度测定技术的精密应用，包括新的测量技术，为可靠评估提供了工具。因此，对于所有未迅速缓解的幼年特发性关节炎患儿，采用标准化的肌肉骨骼系统诊断方法（包括预防和治疗）是必不可少的。在本综述中，将描述诊断和治疗选择，并提出将其纳入临床实践的可能性。
