Tsunoda Akira, Nakao Kentaro, Hiratsuka Kenshi, Tsunoda Yuko, Kusano Mitsuo
General and Gastroenterological Surgery, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan.
Acta Oncol. 2007;46(1):77-82. doi: 10.1080/02841860600847053.
Little is known of how the quality of life (QOL) of patients with colorectal cancer changes with time following an operation, and whether or not there are predictors of QOL after one year in this population. The European Organization for Research and Treatment of Cancer QLQ-C30 QOL questionnaire was administered to patients before their operation for colorectal cancer, and monthly following the operation for up to one year. Multivariate regression analysis was performed to examine the predictors of QOL one year after the operation. One hundred patients with a mean age of 64 years participated. The scores of five QOL dimensions (physical function, role function, fatigue, pain, and dyspnoea) dropped significantly below the preoperative values at one month following the operation. The scores returned to the preoperative values within three months following the operation. The scores of seven QOL dimensions (global QOL, emotional function, social function, insomnia, appetite loss, diarrhea, and financial difficulties) had improved within three months after the operation. Other scores, including cognitive function, nausea and vomiting, and constipation remained unchanged. Stepwise regression analyses showed that preoperative performance status predicted various QOL scales one year following the operation. The overall QOL of colorectal cancer patients became stabilized about three months after the operation.
关于结直肠癌患者术后生活质量（QOL）如何随时间变化，以及该人群术后一年的生活质量是否存在预测因素，目前所知甚少。在结直肠癌患者手术前及术后长达一年的时间里，每月对其进行欧洲癌症研究与治疗组织的QLQ - C30生活质量问卷评估。进行多变量回归分析以检验术后一年生活质量的预测因素。100名平均年龄为64岁的患者参与了研究。术后一个月，五个生活质量维度（身体功能、角色功能、疲劳、疼痛和呼吸困难）的得分显著低于术前值。术后三个月内得分恢复到术前值。七个生活质量维度（总体生活质量、情绪功能、社会功能、失眠、食欲减退、腹泻和经济困难）的得分在术后三个月内有所改善。其他得分，包括认知功能、恶心呕吐和便秘，保持不变。逐步回归分析表明，术前身体状况可预测术后一年的各种生活质量量表。结直肠癌患者的总体生活质量在术后约三个月趋于稳定。
