Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania.
Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, 03101 Vilnius, Lithuania.
Medicina (Kaunas). 2022 Mar 26;58(4):482. doi: 10.3390/medicina58040482.
: Improving early diagnosis and advances in colorectal cancer (CRC) treatment leads to longer survival of these patients. The purpose of this study was to identify the main surgical factors affecting long-term Quality of life (QoL) among colorectal cancer patients after surgery. : QoL was prospectively evaluated in patients undergoing elective colorectal cancer resection operations in three CRC surgery centers of Lithuania using EORTC generic (QLQC-30) and disease-specific (QLQ-CR29) questionnaires at the time of preoperative admission and 1, 24, and 72 months after surgery. QoL was evaluated among different patient groups, diagnostic and treatment modalities, disease, and postoperative complications. Non-parametric tests and multivariate logistic regression models were used for statistical analysis. : Eighty-eight consecutive CRC patients from three institutions were included in the study over a three-month inclusion period, 42 (47.73%) women and 46 (52.27%) men, mean age 64.2 ± 11.5 years. Most tumors were localized in the sigmoid colon and rectum. The largest number of patients had stage III cancer. Twenty-nine patients died-a 6-year survival rate was 67%. 50 of 59 live patients (84.8%) responded to the questionnaire 6 years after their operation. Evaluating changes in quality of life 72 months after surgery with assessments before surgery, both questionnaire responses revealed good long-term CRC surgical treatment results: improved general and functional scale estimates and decreased symptom scale ratings. The multivariate analysis found that age, stoma formation, and rectal cancer were independent risk factors for having worse QoL six years after surgical intervention. : Six years after surgery, QoL returns to preoperative levels. Age, stoma formation, adjuvant treatment, and rectal cancer reduce long-term QoL.
: 改善结直肠癌（CRC）的早期诊断和治疗进展可延长这些患者的生存时间。本研究的目的是确定影响结直肠癌患者手术后长期生活质量（QoL）的主要手术因素。: 在立陶宛的三个 CRC 手术中心，对接受择期结直肠癌症切除术的患者，在术前入院时以及术后 1、24 和 72 个月，使用 EORTC 通用（QLQC-30）和疾病特异性（QLQ-CR29）问卷前瞻性地评估 QoL。根据不同的患者群体、诊断和治疗方式、疾病和术后并发症评估 QoL。采用非参数检验和多变量逻辑回归模型进行统计分析。: 在三个月的纳入期内，从三个机构纳入了 88 例连续的 CRC 患者，其中 42 例（47.73%）为女性，46 例（52.27%）为男性，平均年龄为 64.2±11.5 岁。大多数肿瘤位于乙状结肠和直肠。大多数患者患有 III 期癌症。29 例患者死亡，6 年生存率为 67%。59 例存活患者中有 50 例（84.8%）对术后 6 年的问卷做出了回应。通过将术后 72 个月的生活质量评估与术前评估进行比较，两种问卷都显示出良好的长期 CRC 手术治疗结果：一般和功能量表的估计得到改善，症状量表的评分降低。多变量分析发现，年龄、造口术形成和直肠癌是术后 6 年 QoL 较差的独立危险因素。: 手术后 6 年，QoL 恢复到术前水平。年龄、造口术形成、辅助治疗和直肠癌降低了长期 QoL。
