Berglund Gunilla, Petersson Lena-Marie, Eriksson Karin C, Wallenius Imke, Roshanai Afsaneh, Nordin Karin M, Sjödén Per-Olow, Häggman Michael
Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, S-751 83 Uppsala, Sweden.
Acta Oncol. 2007;46(1):83-9. doi: 10.1080/02841860600857326.
The aim of this study was to evaluate the effect of psychosocial rehabilitation on newly diagnosed prostate cancer patients. The "Between Men" programme consisted of seven weekly sessions of physical training (Phys) alone, information (Info) alone or physical training plus information (PhysInfo). After diagnoses, patients (n = 211) were consecutively included, stratified and randomised to one of four groups: Phys, Info, PhysInfo or standard care control (C). A nurse specialised in urology, an urologist and a physiotherapist performed the interventions. Patients were followed up during one year with mailed standardised questionnaires. It could not be assumed that the "Between Men" programme had any effect on patients' anxiety and depression (HADS). Health-related quality of life (HRQOL) was associated with stage of disease but not with psychosocial intervention. Thus, Physical Function (PF), Role Function (RF) and Fatigue (FA) were inferior among patients with, than without, metastases of prostate cancer both at baseline and at the 12-month follow-up. This randomized study did not demonstrate any significant effect of psychosocial rehabilitation among prostate cancer patients. Considering the low rate (1/2), of included/eligible patients a less complicated design (intervention versus control) would have been preferred in order to increase power.
本研究的目的是评估心理社会康复对新诊断的前列腺癌患者的影响。“男性之间”项目包括七次每周一次的课程，分别为单独的体育训练（Phys）、单独的信息提供（Info）或体育训练加信息提供（PhysInfo）。诊断后，连续纳入患者（n = 211），进行分层并随机分为四组之一：Phys、Info、PhysInfo或标准护理对照组（C）。一名泌尿外科专科护士、一名泌尿科医生和一名物理治疗师进行干预。通过邮寄标准化问卷对患者进行为期一年的随访。不能认为“男性之间”项目对患者的焦虑和抑郁（医院焦虑抑郁量表）有任何影响。健康相关生活质量（HRQOL）与疾病分期相关，但与心理社会干预无关。因此，无论是在基线时还是在12个月随访时，前列腺癌有转移的患者在身体功能（PF）、角色功能（RF）和疲劳（FA）方面均低于无转移的患者。这项随机研究未显示心理社会康复对前列腺癌患者有任何显著影响。考虑到纳入/符合条件患者的比例较低（1/2），为了提高效能，本可以采用一个不太复杂的设计（干预组与对照组）。
