McCormick Beryl
Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
J Natl Compr Canc Netw. 2007 Mar;5(3):345-8. doi: 10.6004/jnccn.2007.0030.
The 2007 National Comprehensive Cancer Network Breast Cancer Clinical Practice Guidelines in Oncology include a consideration for hyperthermia (HT) and radiation for women with recurrent locoregional advanced breast cancers after first-line surgery or radiation failed. Although HT in this setting has been used for several decades, recent reports are few. This article reviews the data from several recent studies, selected because they included at least 100 patients. Unresolved issues of radiation dose, optimal temperature and timing of HT, and quality assurance problems with thermometry are apparent from these studies. Although clearly an effective treatment option in this clinical scenario, more research on HT and radiation is needed before this treatment combination can be considered standard care.
2007年美国国立综合癌症网络（National Comprehensive Cancer Network）《肿瘤学临床实践指南：乳腺癌》提出，对于一线手术或放疗失败后出现复发性局部区域晚期乳腺癌的女性患者，可考虑采用热疗（HT）与放疗联合的治疗方案。尽管热疗在这种情况下已应用了数十年，但近期相关报道较少。本文回顾了近期多项研究的数据，这些研究入选的原因是至少纳入了100例患者。从这些研究中可以明显看出，辐射剂量、热疗的最佳温度和时机以及温度测量的质量保证问题等尚未解决。虽然在这种临床情况下热疗显然是一种有效的治疗选择，但在这种联合治疗方案被视为标准治疗之前，还需要对热疗与放疗进行更多研究。
