Jones Ellen L, Marks Lawrence B, Prosnitz Leonard R
Duke University Medical Center, Durham, NC 27710, USA.
J Natl Compr Canc Netw. 2007 Mar;5(3):339-44. doi: 10.6004/jnccn.2007.0029.
Treatment of a locoregional recurrence of breast cancer after mastectomy remains a clinically challenging problem. Often these patients have undergone prior radiotherapy and chemotherapy. Therapeutic options usually include resection or additional radiation; however, the long-term control rates are often suboptimal with these approaches. Data from several randomized trials suggest that the addition of hyperthermia to radiation can increase the response rate for such local recurrences. Therefore, in settings where the available therapies are unlikely to yield local control (e.g., local/ regional recurrence after prior radiation), a reasonable option to consider is radiation with hyperthermia as a radiation sensitizer. This article reviews the rationale and supporting literature for this recommendation.
乳房切除术后局部区域复发性乳腺癌的治疗仍然是一个具有临床挑战性的问题。这些患者通常之前接受过放疗和化疗。治疗选择通常包括手术切除或额外放疗；然而，这些方法的长期控制率往往不尽人意。几项随机试验的数据表明，放疗联合热疗可提高此类局部复发的缓解率。因此，在现有治疗方法不太可能实现局部控制的情况下（例如，先前放疗后的局部/区域复发），一个合理的选择是考虑将热疗作为放疗增敏剂联合放疗。本文综述了这一推荐的理论依据和相关文献。
