多发性硬化症患者中使用带可变角膜补偿器的GDx进行神经纤维层分析。

Nerve fibre layer analysis with GDx with a variable corneal compensator in patients with multiple sclerosis.

作者信息

Della Mea Giovanni, Bacchetti Sonia, Zeppieri Marco, Brusini Paolo, Cutuli Daniela, Gigli Gian Luigi

机构信息

Department of Ophthalmology, S. Maria della Misericordia Hospital, Udine, Italy.

出版信息

Ophthalmologica. 2007;221(3):186-9. doi: 10.1159/000099299.

DOI:10.1159/000099299

PMID:17440281

Abstract

PURPOSE

To evaluate the ability of GDx with variable corneal compensator (VCC) compared to visual-evoked potentials (VEPs) and standard automated perimetry (SAP) in the detection of early optic nerve damage in patients with multiple sclerosis (MS).

METHODS

46 eyes of 23 MS patients were included. Ten of them had a history of acute retrobulbar optic neuritis. A control group of 20 normal subjects was also included. All subjects underwent a complete ophthalmological examination and testing with SAP, GDx VCC and VEPs.

RESULTS

19 eyes (41.3%) were abnormal with GDx VCC compared to 38 eyes (82.6%) with SAP and 31 (64.4%) with VEPs. In the optic neuritis group, 9 eyes (69.2%) had optic nerve pallor; SAP was abnormal in 8 of these eyes (61.5%) while VEPs and GDx VCC were abnormal in 6 eyes (46.1%). 2/20 eyes (10.0%) in the control group gave a false-positive abnormal result with SAP. GDx VCC and VEP were normal for all the eyes in the control group.

CONCLUSIONS

GDx VCC is less able to detect early defects in MS patients compared to the currently used standard techniques of SAP and VEPs.

摘要

目的

评估采用可变角膜补偿器（VCC）的GDx相较于视觉诱发电位（VEP）和标准自动视野计（SAP）检测多发性硬化症（MS）患者早期视神经损伤的能力。

方法

纳入23例MS患者的46只眼。其中10例有急性球后视神经炎病史。还纳入了20名正常受试者作为对照组。所有受试者均接受了全面的眼科检查以及SAP、GDx VCC和VEP检测。

结果

与SAP检测出异常的38只眼（82.6%）和VEP检测出异常的31只眼（64.4%）相比，GDx VCC检测出19只眼（41.3%）异常。在视神经炎组中，9只眼（69.2%）存在视神经苍白；其中8只眼（61.5%）的SAP异常，6只眼（46.1%）的VEP和GDx VCC异常。对照组中有2/20只眼（10.0%）的SAP出现假阳性异常结果。对照组所有眼的GDx VCC和VEP均正常。