Saglik Yener, Atalar Hakan, Yildiz Yusuf, Basarir Kerem, Erekul Selim
Department of Orthopaedic Surgery and Traumatology, Ankara University, Ankara, Turkey.
Acta Orthop Belg. 2007 Feb;73(1):96-101.
A consensus on the clinical course of fibrous dysplasia has not yet emerged in the literature. We retrospectively evaluated 36 patients who were diagnosed with fibrous dysplasia in our institution and were followed for a mean duration of 56.5 months (range 7-210 months). Their mean age was 25.8 years (range 5-67 years); 46.7% were male. The most frequent presenting complaints were pain (66% of patients) and pathological fracture (20%). Osteosarcoma developed in one patient 20 years after he had undergone radiation therapy for fibrous dysplasia in the tibia. Mazabraud syndrome was encountered in two patients, and aneurysmal bone cyst associated with fibrous dysplasia was seen in one patient. Fibrous dysplasia is generally considered a static disease, but with long-term follow-up it is found to have a more dynamic nature. For this reason, patients with fibrous dysplasia should be followed carefully over the long-term.
关于骨纤维发育不良的临床病程，目前文献中尚未达成共识。我们回顾性评估了我院36例诊断为骨纤维发育不良的患者，平均随访时间为56.5个月（范围7 - 210个月）。他们的平均年龄为25.8岁（范围5 - 67岁）；46.7%为男性。最常见的主诉是疼痛（66% 的患者）和病理性骨折（20%）。1例患者在接受胫骨骨纤维发育不良放射治疗20年后发生骨肉瘤。2例患者出现马扎布罗德综合征（Mazabraud syndrome）, 1例患者出现与骨纤维发育不良相关的动脉瘤样骨囊肿。骨纤维发育不良通常被认为是一种静止性疾病，但长期随访发现它具有更动态的性质。因此，骨纤维发育不良患者应长期接受仔细随访。
