Yabut S M, Kenan S, Sissons H A, Lewis M M
Hospital for Joint Diseases Orthopaedic Institute, New York, New York.
Clin Orthop Relat Res. 1988 Mar(228):281-9.
A 34-year-old man developed a spindle-cell sarcoma originating in a preexisting lesion of monostotic fibrous dysplasia. A review of the literature reveals 83 cases of a malignant degeneration in fibrous dysplasia; osteosarcoma was the most common type of tumor. The next most common were fibrosarcoma and chondrosarcoma. The malignant tumor usually developed in the third or fourth decade of life. The most frequent anatomic sites were the craniofacial bones, the femur, and the tibia. Twenty-three of the 83 cases were treated with local radiation. In fibrous dysplasia, any abrupt alteration in the clinical course, manifested by pain and swelling, raises the possibility of malignant degeneration.
一名34岁男性患有一种起源于单骨型纤维发育不良的既往病变的梭形细胞肉瘤。文献回顾显示，纤维发育不良中有83例发生恶性变；骨肉瘤是最常见的肿瘤类型。其次最常见的是纤维肉瘤和软骨肉瘤。恶性肿瘤通常在生命的第三个或第四个十年出现。最常见的解剖部位是颅面骨、股骨和胫骨。83例中有23例接受了局部放疗。在纤维发育不良中，临床病程中任何以疼痛和肿胀为表现的突然改变都增加了恶性变的可能性。
