Mørch L S, Johansen D, Løkkegaard E, Hundrup Y A, Grønbaek M
Centre for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark.
Eur J Clin Nutr. 2008 Jun;62(6):817-22. doi: 10.1038/sj.ejcn.1602799. Epub 2007 May 23.
BACKGROUND/OBJECTIVE: Moderate alcohol consumption has beneficial effects on survival. Sex differences, however, have been suggested implying less beneficial effect among women. We examined the impact of alcohol consumed on weekdays and at weekends, respectively, on risk of death among women.
At baseline in 1993, a total of 17 772 female members of the Danish Nurse Association completed questionnaires on alcohol intake and other lifestyle factors. The influence of alcohol intake on risk of death was analyzed using Cox proportional hazard model.
Alcohol intake of 1-3 drinks per week was associated with the lowest risk of death. Intake above six drinks per weekend (Friday through Sunday) increased risk of death from all causes by 3% for each additional drink consumed per weekend (corresponding to an increased risk by 9% per drink per weekend day). Consumption of one or more drinks per weekday (Monday, Tuesday, Wednesday or Thursday) increased risk by 4% for each additional drink consumed per day.
The results indicated an increasing risk of death for intake above six drinks per weekend and of one or more drinks per weekday.
背景/目的：适度饮酒对生存有益。然而，有研究表明存在性别差异，即饮酒对女性的益处可能较少。我们分别研究了工作日和周末饮酒对女性死亡风险的影响。
1993年基线调查时，丹麦护士协会的17772名女性成员完成了关于饮酒量及其他生活方式因素的问卷调查。采用Cox比例风险模型分析饮酒量对死亡风险的影响。
每周饮酒1 - 3杯与最低死亡风险相关。每个周末（周五至周日）饮酒超过6杯，每多喝一杯，全因死亡风险增加3%（相当于每个周末日每多喝一杯死亡风险增加9%）。每个工作日（周一、周二、周三或周四）饮酒1杯及以上，每天每多喝一杯死亡风险增加4%。
结果表明，每个周末饮酒超过6杯以及每个工作日饮酒1杯及以上会增加死亡风险。
