Speroni E, Cervellati R, Costa S, Dall'Acqua S, Guerra M C, Panizzolo C, Utan A, Innocenti G
Department of Pharmacology, via Irnerio 48, Bologna University, 40126 Bologna, Italy.
Phytother Res. 2007 Jul;21(7):684-9. doi: 10.1002/ptr.2145.
According to folk medicine some species belonging to the genus Cyclamen were used for their biological activities. Early investigation of the different species of the genus resulted in the isolation of triterpenic saponins. No phytochemical and biological data are available on C. repandum. As part of a series of phytochemical investigations for bioactive compounds from medicinal plants, Cyclamen repandum S. et S. was investigated. The present study sought to find the antiinflammatory and antinociceptive activities of C. repandum tubers in rats and mice. A preliminary screening was conducted with three different extracts in the tests used, particularly the paw edema and the writhing tests. Subsequently some saponins isolated from the ME extract, the more effective one, have been identified. This paper also describes the results of fractionation and bioassay guided chemical studies. Chemical investigation of the active extract afforded the isolation and characterization of six triterpenic saponins. The possible antiinflammatory and analgesic properties were investigated as the saponin content of the fractions allows to speculate on such aspect.
根据民间医学，仙客来属的一些物种因其生物活性而被使用。对该属不同物种的早期研究导致了三萜皂苷的分离。关于仙客来没有植物化学和生物学数据。作为对药用植物生物活性化合物进行一系列植物化学研究的一部分，对仙客来进行了研究。本研究旨在寻找仙客来块茎在大鼠和小鼠中的抗炎和抗伤害感受活性。在所用测试中，特别是爪肿胀和扭体试验中，用三种不同提取物进行了初步筛选。随后，从更有效的甲醇提取物中分离出了一些皂苷并进行了鉴定。本文还描述了分级分离和生物测定指导下的化学研究结果。对活性提取物的化学研究得到了六种三萜皂苷的分离和表征。由于各馏分中的皂苷含量有助于推测这方面的情况，因此对其可能的抗炎和镇痛特性进行了研究。
