Kiernan Daniel F, Hariprasad Seenu M, Chin Eric K, Kiernan Claire L, Rago James, Mieler William F
University of Chicago Hospitals, Ophthalmology and Visual Sciences, Chicago, Illinois, USA.
Am J Ophthalmol. 2009 Feb;147(2):267-275.e2. doi: 10.1016/j.ajo.2008.08.018. Epub 2008 Oct 17.
To compare Cirrus Fourier-domain optical coherence tomography (OCT) with Stratus time-domain OCT for imaging retinal diseases and quantifying retinal thickness (RT) of all nine OCT zones, central macular thickness, and average macular thickness in eyes with and without macular edema.
Prospective comparison between two OCT systems.
RT measurements were performed in 120 eyes of 60 patients suspected of having increased retina thickness using both Stratus and Cirrus OCT on the same day. Twenty-one eyes had both 512 x 128 and 200 x 200 Cirrus cube scans done.
Data from 101 eyes (53 patients) were analyzed; 46 eyes (45.5%) had macular edema on clinical examination (Group 1), whereas 55 eyes (54.4%) had no clinical evidence of macular edema (Group 2). There was modest correlation between all thickness measurements in 909 zones and each group (range of Pearson correlation, 0.51 to 0.89) and average value was significantly greater when measured with Cirrus OCT for all eyes (mean difference, 43.2 microm; P < .0001). There were few measurement differences between different resolution Cirrus cube scans.
Cirrus OCT measures RT approximately 43 microm greater than Stratus OCT, which is likely attributable to Cirrus OCT detection of the outer band of the retinal pigment epithelium vs Stratus OCT detection of the inner/outer segment photoreceptor junction. All zones showed a wide degree of variability in correlation. Both Cirrus cube scans provide similar data. Future studies comparing these systems might consider utilizing average macular thickness values, which reflect macular volume and may provide more consistent measurements.
比较Cirrus傅里叶域光学相干断层扫描（OCT）与Stratus时域OCT在视网膜疾病成像以及量化有无黄斑水肿眼睛的所有九个OCT区域的视网膜厚度（RT）、中心黄斑厚度和平均黄斑厚度方面的差异。
两种OCT系统的前瞻性比较。
同一天使用Stratus和Cirrus OCT对60例疑似视网膜厚度增加患者的120只眼睛进行RT测量。21只眼睛同时进行了512×128和200×200的Cirrus立方体扫描。
分析了101只眼睛（53例患者）的数据；46只眼睛（45.5%）经临床检查有黄斑水肿（第1组），而55只眼睛（54.4%）无黄斑水肿的临床证据（第2组）。909个区域的所有厚度测量值在两组之间存在适度相关性（Pearson相关性范围为0.51至0.89），并且所有眼睛使用Cirrus OCT测量时的平均值显著更高（平均差异为43.2微米；P <.0001）。不同分辨率的Cirrus立方体扫描之间测量差异很少。
Cirrus OCT测量的RT比Stratus OCT大约厚43微米，这可能归因于Cirrus OCT检测视网膜色素上皮的外带，而Stratus OCT检测内/外段光感受器交界处。所有区域在相关性方面都表现出很大程度的变异性。两种Cirrus立方体扫描提供的数据相似。未来比较这些系统的研究可能会考虑使用平均黄斑厚度值，其反映黄斑体积并可能提供更一致的测量结果。
