Yang Y R, Craig P S, Ito A, Vuitton D A, Giraudoux P, Sun T, Williams G M, Huang Z, Li Z, Wang Y, Teng J, Li Y, Huang L, Wen H, Jones M K, McManus D P
Ningxia Medical College, Yinchuan, Ningxia Hui Autonomous Region, China.
Trop Med Int Health. 2007 May;12(5):637-46. doi: 10.1111/j.1365-3156.2007.01834.x.
We correlated ultrasound (US) imaging classifications for human alveolar echinococcosis (AE) and cystic echinococcosis (CE) with serology (ELISA and immunoblotting (IB) incorporating native and recombinant/purified echinococcal antigens) in community surveys (2001-2003) and follow-up (2002 and 2003) of US-confirmed cases in Ningxia, China. One hundred and seventy-one cases (96 with AE, 75 with CE) were identified; of these, US classification and serological data were obtained for 142 and 112 cases, respectively. Seropositive-rates increased in CE patients with highly viable unilocular cyst lesions (Types CL, CE 1 or CE 2) to degenerating primary lesions (CE 3), but then decreased in subjects with inactive (CE 4) or dead (CE 5) cysts. In contrast, there was a constant increase in seropositivity from the early (P1, P2) to the advanced stages (P3, P4) with AE cases. For US-confirmed cases, follow-up by US combined with serology is invaluable for studying the clinical progression of echinococcosis and for detecting recurrent cysts or reinfection post-treatment.
在2001 - 2003年的社区调查以及对中国宁夏超声确诊病例在2002年和2003年的随访中，我们将人体肺泡型棘球蚴病（AE）和囊型棘球蚴病（CE）的超声（US）成像分类与血清学（酶联免疫吸附测定法（ELISA）以及采用天然和重组/纯化棘球蚴抗原的免疫印迹法（IB））进行了关联分析。共识别出171例病例（96例AE，75例CE）；其中，分别获得了142例和112例病例的超声分类和血清学数据。囊型棘球蚴病患者中，具有高度存活的单房囊肿病变（CL型、CE 1型或CE 2型）至退化的原发性病变（CE 3型）的血清阳性率升高，但在具有不活动（CE 4型）或死亡（CE 5型）囊肿的患者中则下降。相比之下，肺泡型棘球蚴病病例从早期（P1、P2）到晚期（P3、P4）血清阳性率持续升高。对于超声确诊的病例，超声联合血清学进行随访对于研究棘球蚴病的临床进展以及检测治疗后复发囊肿或再感染具有重要价值。
