Keenan Joseph M, Goulson Melanie, Shamliyan Tatyana, Knutson Nathan, Kolberg Lore, Curry Leslie
University of Minnesota, Medical School, Department of Family Medicine and Community Health, MMC 381, Minneapolis, MN 55455, USA.
Br J Nutr. 2007 Jun;97(6):1162-8. doi: 10.1017/S0007114507682968. Epub 2007 Apr 20.
Barley, like oats, is a rich source of the soluble fibre beta-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied. Therefore, we evaluated the LDL-C-lowering effect of a concentrated barley beta-glucan (BBG) extract as a vehicle to deliver this potential health benefit of barley. In a 10-week blinded controlled study, subjects were randomized to one of four treatment groups or control. Treatment groups included either high molecular weight (HMW) or low molecular weight (LMW) BBG at both 3 and 5 g doses. Treatment was delivered twice per day with meals in the form of two functional food products: a ready-to-eat cereal and a reduced-calorie fruit juice beverage. Levels of total cholesterol, LDL-C, HDL-cholesterol (HDL-C), and TAG were determined at baseline and after 6 weeks of treatment. The study group comprised 155 subjects. All treatments were well tolerated and after 6 weeks of treatment the mean LDL-C levels fell by 15 % in the 5 g HMW group, 13 % in the 5 g LMW group and 9 % in both the 3 g/d groups, versus baseline. Similar results were observed for total cholesterol. HDL-C levels were unchanged by treatment. Concentrated BBG significantly improves LDL-C and total cholesterol among moderately dyslipidaemic subjects. Food products containing concentrated BBG should be considered an effective option for improving blood lipids.
大麦与燕麦一样，是可溶性纤维β-葡聚糖的丰富来源，已证明其能显著降低低密度脂蛋白胆固醇（LDL-C）。然而，对大麦食品的研究较少。因此，我们评估了浓缩大麦β-葡聚糖（BBG）提取物降低LDL-C的效果，以此作为传递大麦这种潜在健康益处的载体。在一项为期10周的双盲对照研究中，受试者被随机分为四个治疗组或对照组之一。治疗组包括3克和5克剂量的高分子量（HMW）或低分子量（LMW）BBG。治疗以两种功能性食品的形式，每天随餐服用两次：即食谷物和低热量果汁饮料。在基线和治疗6周后测定总胆固醇、LDL-C、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TAG）水平。研究组包括155名受试者。所有治疗耐受性良好，治疗6周后，与基线相比，5克HMW组的平均LDL-C水平下降了15%，5克LMW组下降了13%，两个3克/天组均下降了9%。总胆固醇也观察到类似结果。治疗后HDL-C水平未发生变化。浓缩BBG能显著改善中度血脂异常受试者的LDL-C和总胆固醇水平。含有浓缩BBG的食品应被视为改善血脂的有效选择。
