Cole Michael A, Castellon Steven A, Perkins Adam C, Ureno Oscar S, Robinet Marta B, Reinhard Matthew J, Barclay Terry R, Hinkin Charles H
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA.
J Int Neuropsychol Soc. 2007 May;13(3):549-54. doi: 10.1017/S135561770707066X.
Human immunodeficiency virus (HIV)-infected adults frequently evidence both neurocognitive and psychiatric dysfunction. It was hypothesized that apathy and irritability, but not anxiety and depression, are related to HIV effects on frontal-subcortical systems. This hypothesis was evaluated by determining the degree to which these psychiatric features are associated with neurocognitive functioning that is dependent upon frontal-subcortical circuitry and, therefore, thought to be sensitive to the central nervous system effects of HIV. Rating scales assessing irritability, apathy, depression, and anxiety and a dual-task paradigm were administered to 189 HIV-seropositive (HIV+) and 53 HIV-seronegative participants. Deficits in dual-task performance and greater anxiety, depression, apathy, and irritability were observed in HIV+ participants. Simultaneous multivariate regression and communality analyses revealed that only apathy and irritability were associated with dual-task performance in HIV+ participants. Thus, these findings suggest that apathy and irritability, but not depression and anxiety, are likely associated with the effects of HIV on frontal-subcortical circuitry.
感染人类免疫缺陷病毒（HIV）的成年人常常表现出神经认知和精神功能障碍。研究假设冷漠和易怒与HIV对额叶-皮质下系统的影响有关，而焦虑和抑郁则与之无关。通过确定这些精神特征与依赖额叶-皮质下神经回路的神经认知功能的关联程度来评估这一假设，因此认为该神经认知功能对HIV的中枢神经系统影响敏感。对189名HIV血清阳性（HIV+）参与者和53名HIV血清阴性参与者进行了评估易怒、冷漠、抑郁和焦虑的评定量表以及双任务范式测试。在HIV+参与者中观察到双任务表现缺陷以及更严重的焦虑、抑郁、冷漠和易怒。同时进行的多元回归和共同性分析显示，在HIV+参与者中，只有冷漠和易怒与双任务表现相关。因此，这些发现表明冷漠和易怒可能与HIV对额叶-皮质下神经回路的影响有关，而抑郁和焦虑则不然。
