Raftos D A, Cooper E L
Department of Anatomy and Cell Biology, UCLA School of Medicine, University of California 90024.
J Exp Zool. 1991 Dec;260(3):391-400. doi: 10.1002/jez.1402600313.
Lymphocyte-like hemocytes (LLCs) of solitary tunicates proliferate in response to allogeneic stimuli. In vitro labeling of proliferative hemocytes from the solitary species Styela clava revealed significantly greater proliferative activity among individuals immunized with allogeneic tissue as opposed to autogeneically primed and naïve animals. Enhanced proliferation was restricted to discrete crypts of dividing cells within the body wall of recipients. Here, increased proliferative activity was specifically associated with LLCs. These data support previous results which implicated LLC activity with immunological memory that is evident in allograft rejection. Hence, it is postulated that adaptive histoincompatibility responses in solitary tunicates depend upon the specific proliferation of immunocompetent cells.
单体被囊动物的淋巴细胞样血细胞（LLCs）会对同种异体刺激产生增殖反应。对单体物种柄海鞘增殖血细胞的体外标记显示，与自体免疫和未免疫的动物相比，用同种异体组织免疫的个体中增殖活性显著更高。增强的增殖仅限于受体体壁内分裂细胞的离散隐窝。在这里，增殖活性的增加与LLCs特异性相关。这些数据支持了先前的结果，即LLC活性与同种异体移植排斥中明显的免疫记忆有关。因此，推测单体被囊动物的适应性组织不相容反应取决于免疫活性细胞的特异性增殖。
