Fuller Margaret T, Spradling Allan C
Departments of Developmental Biology and Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science. 2007 Apr 20;316(5823):402-4. doi: 10.1126/science.1140861.
Drosophila male and female germline stem cells (GSCs) are sustained by niches and regulatory pathways whose common principles serve as models for understanding mammalian stem cells. Despite striking cellular and genetic similarities that suggest a common evolutionary origin, however, male and female GSCs also display important differences. Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production.
果蝇的雄性和雌性生殖系干细胞（GSCs）由微环境和调控通路维持，这些共同的原理可作为理解哺乳动物干细胞的模型。然而，尽管在细胞和基因层面存在显著相似性，暗示着共同的进化起源，但雄性和雌性GSCs也存在重要差异。详细比较这两种干细胞及其微环境，可能会揭示共同的遗传特性是如何适应雄性和雌性配子产生的不同需求的。
