Dashti Hussein M, Mathew Thazhumpal C, Khadada Mousa, Al-Mousawi Mahdi, Talib Husain, Asfar Sami K, Behbahani Abdulla I, Al-Zaid Naji S
Department of Surgery, Faculty of Medicine, Kuwait University, PO Box 24923, 13110 Safat, Kuwait.
Mol Cell Biochem. 2007 Aug;302(1-2):249-56. doi: 10.1007/s11010-007-9448-z. Epub 2007 Apr 20.
Obesity is closely linked to the incidence of type II diabetes. It is found that effective management of body weight and changes to nutritional habits especially with regard to the carbohydrate content and glycemic index of the diet have beneficial effects in obese subjects with glucose intolerance. Previously we have shown that ketogenic diet is quite effective in reducing body weight. Furthermore, it favorably alters the cardiac risk factors even in hyperlipidemic obese subjects. In this study the effect of ketogenic diet in obese subjects with high blood glucose level is compared to those with normal blood glucose level for a period of 56 weeks.
A total of 64 healthy obese subjects with body mass index (BMI) greater than 30, having high blood glucose level and those subjects with normal blood glucose level were selected in this study. The body weight, body mass index, blood glucose level, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, urea and creatinine were determined before and at 8, 16, 24, 48, and 56 weeks after the administration of the ketogenic diet.
The body weight, body mass index, the level of blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and urea showed a significant decrease from week 1 to week 56 (P < 0.0001), whereas the level of HDL-cholesterol increased significantly (P < 0.0001). Interestingly these changes were more significant in subjects with high blood glucose level as compared to those with normal blood glucose level. The changes in the level of creatinine were not statistically significant.
This study shows the beneficial effects of ketogenic diet in obese diabetic subjects following its long-term administration. Furthermore, it demonstrates that in addition to its therapeutic value, low carbohydrate diet is safe to use for a longer period of time in obese diabetic subjects.
肥胖与II型糖尿病的发病率密切相关。研究发现，有效管理体重以及改变营养习惯，尤其是饮食中的碳水化合物含量和血糖指数，对葡萄糖不耐受的肥胖受试者具有有益影响。此前我们已经表明生酮饮食在减轻体重方面相当有效。此外，即使在高脂血症肥胖受试者中，它也能有利地改变心脏危险因素。在本研究中，将生酮饮食对高血糖肥胖受试者的影响与血糖正常的受试者进行了为期56周的比较。
本研究共选取了64名健康肥胖受试者，其体重指数（BMI）大于30，包括高血糖受试者和血糖正常的受试者。在给予生酮饮食前以及饮食后8周、16周、24周、48周和56周时，测定体重、体重指数、血糖水平、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、尿素和肌酐。
从第1周到第56周，体重、体重指数、血糖水平、总胆固醇、低密度脂蛋白胆固醇、甘油三酯和尿素水平均显著下降（P < 0.0001），而高密度脂蛋白胆固醇水平显著升高（P < 0.0001）。有趣的是，与血糖正常的受试者相比，这些变化在高血糖受试者中更为显著。肌酐水平的变化无统计学意义。
本研究表明生酮饮食长期应用于肥胖糖尿病受试者具有有益效果。此外，它还证明了除治疗价值外，低碳水化合物饮食在肥胖糖尿病受试者中长时间使用是安全的。
