García-Peláez B, Vilà R, Remesar X
Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Horm Metab Res. 2007 Apr;39(4):278-81. doi: 10.1055/s-2007-973813.
To determine whether oleoyl-estrone can be transferred from mothers to their offspring either during pregnancy or lactation, a gavage of tracer dose of (3)H-Oleoyl-estrone was given to 21-day pregnant rats and to lactating rats on day 15 after delivery. In pregnant rats, the label was found in maternal blood as well as in liver and fetal serum, the latter showing the highest specific activity observed. In lactating rats, oleoyl-estrone label was found both in the mammary gland and maternal serum; in the pups, label was found in their stomach contents (i.e., clotted milk) and serum. The results suggest that the placenta effectively blocks the passage of oleoyl-estrone to the fetuses probably because of its high esterase activity. On the other hand, oleoyl-estrone is easily transferred from dams to pups, as a component of milk.
为了确定油酰雌酮在孕期或哺乳期是否能够从母体转移至子代，给妊娠21天的大鼠和产后第15天的泌乳大鼠灌胃给予示踪剂量的(3)H-油酰雌酮。在妊娠大鼠中，标记物在母体血液、肝脏和胎儿血清中均被发现，后者显示出所观察到的最高比活性。在泌乳大鼠中，油酰雌酮标记物在乳腺和母体血清中均被发现；在幼崽中，标记物在其胃内容物（即凝乳）和血清中被发现。结果表明，胎盘可能因其高酯酶活性而有效地阻断了油酰雌酮向胎儿的转运。另一方面，油酰雌酮作为乳汁的一种成分很容易从母鼠转移至幼崽。
