Sanchis D, Balada F, Grasa M M, Virgili J, Monserrat C, Fernández-López J A, Remesar X, Alemany M
Centre d'Investigació, Laboratoris S.A.L.V.A.T., S.A., Esplugues de Llobregat, Barcelona, Spain.
Mol Cell Biochem. 1997 Dec;177(1-2):153-7. doi: 10.1023/a:1006849128697.
Female adult rats were injected in the jugular vein with oleoyl-3H-estrone incorporated into liposomes. The label rapidly disappeared from the blood, being taken up by the tissues, mainly liver, spleen and lung, which filtered most of the label. However, many other tissues, such as the heart, brown adipose tissue, adrenals and visceral fat incorporated significant amounts of oleoyl-estrone. The analysis of the form in which the label remained 10 min after the injection showed that it was hydrolysed in a large proportion even in liver and lungs. However, in most tissues (brain, brown and white - periovaric - adipose tissues and ovaries), intact oleoyl-estrone accounted for less than one quarter of all tissue label, and less than 10% in the case of subcutaneous adipose tissue and uterus. This rapid destruction of oleoyl-estrone is in agreement with the active role of this compound in the control of body weight.
成年雌性大鼠经颈静脉注射掺入脂质体的油酰-3H-雌酮。标记物迅速从血液中消失，被组织摄取，主要是肝脏、脾脏和肺，这些组织过滤了大部分标记物。然而，许多其他组织，如心脏、棕色脂肪组织、肾上腺和内脏脂肪也摄取了大量的油酰雌酮。注射后10分钟对标记物留存形式的分析表明，即使在肝脏和肺中，它也有很大比例被水解。然而，在大多数组织（脑、棕色和白色——卵巢周围——脂肪组织以及卵巢）中，完整的油酰雌酮占所有组织标记物的比例不到四分之一，皮下脂肪组织和子宫的比例则不到10%。油酰雌酮的这种快速分解与该化合物在体重控制中的积极作用是一致的。
