Braga A J, Chidley K
Department of Anaesthetics and Intensive Care, Gloucestershire Royal Hospital, Gloucester, UK.
Anaesthesia. 2007 May;62(5):524-7. doi: 10.1111/j.1365-2044.2006.04913.x.
We report a case of intentional overdose in a 29-year-old male with two of the newer anti-epileptic agents, lamotrigine and pregabalin. To our knowledge, this case report details the highest plasma levels of lamotrigine ever recorded in the literature. The patient presented with seizures and a reduced level of consciousness. Management of these and subsequent complications centres on supportive care in the high dependency and intensive therapy units.
我们报告一例29岁男性故意过量服用两种新型抗癫痫药物拉莫三嗪和普瑞巴林的病例。据我们所知，本病例报告详细记录了文献中所报道的拉莫三嗪最高血浆浓度。患者出现癫痫发作且意识水平降低。对这些症状及后续并发症的处理主要集中在高依赖病房和重症监护病房的支持性治疗。
