Venkatraman N, O'Neil D, Hall A P
Acute Care Common Stem, University Hospitals of Leicester NHS Trust, Intensive Care Unit, Leicester Royal Infirmary, Leicester, United Kingdom.
J Postgrad Med. 2008 Oct-Dec;54(4):316-7. doi: 10.4103/0022-3859.43516.
Lamotrigine is a commonly used agent for seizure control in epilepsy. There are limited data on the adverse effects of lamotrigine in overdose. We report a number of serious side-effects associated with a large overdose of lamotrigine. A 23-year-old female presented to the emergency department after taking an intentional overdose of 9.2 g of lamotrigine, 56 mg of chlorpheniramine, and 220 mg of citalopram. On admission, she had a reduced level of consciousness and electrocardiographic abnormalities; a widened QRS and a prolonged corrected QT (QTc) interval. Prompt treatment with early intubation, along with the use of magnesium for cardioprotection and administration of sodium bicarbonate may have aided in a quick recovery with a short intensive care stay and good outcome.
拉莫三嗪是癫痫治疗中常用的控制癫痫发作的药物。关于过量服用拉莫三嗪的不良反应的数据有限。我们报告了大量过量服用拉莫三嗪相关的严重副作用。一名23岁女性故意过量服用9.2克拉莫三嗪、56毫克氯苯那敏和220毫克西酞普兰后就诊于急诊科。入院时，她意识水平降低且有心电图异常；QRS波增宽和校正QT（QTc）间期延长。早期插管的及时治疗，以及使用镁进行心脏保护和给予碳酸氢钠，可能有助于其快速康复，在重症监护病房停留时间短且预后良好。
