慢性肾衰竭中的听力损失——血液透析后的听力阈值变化
Hearing loss in chronic renal failure-hearing threshold changes following haemodialysis.
作者信息
Gatland D, Tucker B, Chalstrey S, Keene M, Baker L
机构信息
ENT Department, St Bartholomew's Hospital, London.
出版信息
J R Soc Med. 1991 Oct;84(10):587-9. doi: 10.1177/014107689108401006.
The prevalence of sensorineural hearing loss, measured by pure tone audiometry, was determined in 66 patients with chronic renal failure and threshold changes following haemodialysis were measured in 31 patients. The incidence of hearing loss was 41% in the low, 15% in the middle and 53% in the high frequency ranges respectively. No correlations with weight changes, haematocrit, metabolic bone disease or ototoxic drug history were found. Of 62 ears studied, 38% had a decrease in low frequency threshold after dialysis and 9% had an increase. Threshold in 22/31 ears with pre-existing low frequency loss altered after dialysis with little change in other frequencies and no correlation with weight changes. In conclusion, we find a high incidence of low and high frequency hearing losses in chronic renal failure patients. Fluctuation in low frequencies with dialysis is common. Possible mechanisms include treatment induced changes in fluid and electrolyte composition of endolymph.
通过纯音听力测定法测定了66例慢性肾衰竭患者感音神经性听力损失的患病率，并对31例患者进行了血液透析后的阈值变化测定。听力损失的发生率在低频范围为41%，中频范围为15%，高频范围为53%。未发现与体重变化、血细胞比容、代谢性骨病或耳毒性药物史相关。在研究的62只耳朵中，38%在透析后低频阈值降低，9%升高。31只已有低频听力损失的耳朵中，22只在透析后阈值发生改变，其他频率变化不大，且与体重变化无关。总之，我们发现慢性肾衰竭患者低频和高频听力损失的发生率较高。透析时低频波动很常见。可能的机制包括治疗引起的内淋巴液和电解质成分变化。
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