儿童期慢性肾衰竭患者的感音神经性听力损失。
Sensorineural hearing loss in patients reaching chronic renal failure in childhood.
作者信息
Mancini M L, Dello Strologo L, Bianchi P M, Tieri L, Rizzoni G
机构信息
Division of Nephrology, Bambino Gesù Children's Research Hospital, Rome, Italy.
出版信息
Pediatr Nephrol. 1996 Feb;10(1):38-40. doi: 10.1007/BF00863438.
The incidence of sensorineural hearing loss (SNHL) was investigated in 68 patients who reached chronic renal failure (CRF) in childhood with the aim of identifying possible risk factors. Tests were carried out by means of pure-tone and impedance audiometry. SNHL was found in 29% of patients on conservative treatment, 28% of patients on hemodialysis, and 47% after renal transplantation. Differences among groups were not significant. A significant correlation was found with the administration of ototoxic drugs (aminoglycosides and furosemide). We hypothesize that SNHL may be reduced in patients with CRF or on renal replacement therapy by strictly monitoring ototoxic therapy.
为了确定可能的风险因素，我们对68例儿童期达到慢性肾衰竭（CRF）的患者进行了感音神经性听力损失（SNHL）发病率的调查。通过纯音和阻抗测听法进行测试。结果发现，接受保守治疗的患者中29%患有SNHL，接受血液透析的患者中28%患有SNHL，肾移植后患者中47%患有SNHL。组间差异无统计学意义。发现与耳毒性药物（氨基糖苷类和呋塞米）的使用存在显著相关性。我们推测，通过严格监测耳毒性治疗，CRF患者或接受肾脏替代治疗的患者中SNHL可能会减少。
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