Browning G G, Gatehouse S, Lowe G D
Lancet. 1986 Jan 18;1(8473):121-3. doi: 10.1016/s0140-6736(86)92261-0.
The cause of sensorineural hearing impairment is unknown in a high proportion of patients. Since ischaemia is a possible factor, the relation between hearing threshold and blood viscosity, plasma viscosity, and haematocrit was investigated in 49 patients with idiopathic hearing loss, taking into account age, sex, smoking, and socioeconomic group. Hearing thresholds were unrelated to haematocrit or low-shear blood viscosity. Hearing impairment at high frequencies was directly related to high-shear blood viscosity and inversely related to plasma viscosity. The derived measure of red-cell rigidity was significantly related at all frequencies to hearing thresholds. A second study of 92 subjects from a population sample confirmed the inverse relation with plasma viscosity and lack of relation with haematocrit. Increased pure-tone thresholds appear to be related to increased red-cell rigidity; this may be an important factor in sensorineural hearing impairment with implications for diagnosis and prevention.
在很大一部分患者中，感音神经性听力障碍的病因尚不清楚。由于缺血是一个可能的因素，因此在49例特发性听力损失患者中，研究了听力阈值与血液粘度、血浆粘度和血细胞比容之间的关系，同时考虑了年龄、性别、吸烟和社会经济群体等因素。听力阈值与血细胞比容或低切变血液粘度无关。高频听力障碍与高切变血液粘度直接相关，与血浆粘度呈负相关。推导得出的红细胞刚性指标在所有频率下均与听力阈值显著相关。对来自人群样本的92名受试者进行的第二项研究证实了与血浆粘度的负相关以及与血细胞比容无关。纯音阈值升高似乎与红细胞刚性增加有关；这可能是感音神经性听力障碍的一个重要因素，对诊断和预防具有重要意义。
