Pialoux Gilles, Gaüzère Bernard-Alex, Jauréguiberry Stéphane, Strobel Michel
Hôpital Tenon, Service des Maladies Infectieuses et Tropicales, Paris, France.
Lancet Infect Dis. 2007 May;7(5):319-27. doi: 10.1016/S1473-3099(07)70107-X.
Chikungunya is an arboviral disease transmitted by aedes mosquitoes. The virus was first isolated in 1953 in Tanzania. Chikungunya virus is a member of the genus Alphavirus and the family Togaviridae. The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia. The word chikungunya, used for both the virus and the disease, means "to walk bent over" in some east African languages, and refers to the effect of the joint pains that characterise this dengue-like infection. Chikungunya is a specifically tropical disease, but it is geographically restricted and outbreaks are relatively uncommon. It is only occasionally observed in travellers and military personnel. More than 266 000 people have been infected during the ongoing outbreak in Réunion, in which Aedes albopictus is the presumed vector. In the ongoing Indian outbreak, in which Aedes aegypti is the presumed vector, 1 400 000 cases of chikungunya were reported during 2006. The reasons for the re-emergence of chikungunya on the Indian subcontinent, and for its unprecedented incidence rate in the Indian Ocean region, are unclear. Plausible explanations include increased tourism, chikungunya virus introduction into a naive population, and viral mutation.
基孔肯雅热是一种由伊蚊传播的虫媒病毒病。该病毒于1953年在坦桑尼亚首次分离出来。基孔肯雅病毒是甲病毒属和披膜病毒科的成员。该病通常表现为一种急性疾病,其特征为发热、皮疹和使人丧失能力的关节痛。“基孔肯雅”这个词,既用于指病毒,也用于指疾病,在一些东非语言中的意思是“弯腰行走”,指的是这种类似登革热感染的关节疼痛的影响。基孔肯雅热是一种典型的热带疾病,但在地理上受到限制,疫情相对不常见。它只偶尔在旅行者和军事人员中出现。在留尼汪岛正在发生的疫情中,已感染超过26.6万人,据推测白纹伊蚊是传播媒介。在印度正在发生的疫情中,据推测埃及伊蚊是传播媒介,2006年报告了140万例基孔肯雅热病例。基孔肯雅热在印度次大陆重新出现以及在印度洋地区出现前所未有的发病率的原因尚不清楚。合理的解释包括旅游业增加、基孔肯雅病毒传入易感人群以及病毒突变。