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一种新型耐头孢他啶的CTX-M超广谱β-内酰胺酶CTX-M-55在泰国社区获得性感染和医院获得性感染中均有出现。

The emergence of a novel ceftazidime-resistant CTX-M extended-spectrum beta-lactamase, CTX-M-55, in both community-onset and hospital-acquired infections in Thailand.

作者信息

Kiratisin Pattarachai, Apisarnthanarak Anucha, Saifon Piyawan, Laesripa Chaitat, Kitphati Rungrueng, Mundy Linda M

机构信息

Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

出版信息

Diagn Microbiol Infect Dis. 2007 Jul;58(3):349-55. doi: 10.1016/j.diagmicrobio.2007.02.005. Epub 2007 Apr 20.

Abstract

We report a novel CTX-M type of extended-spectrum beta-lactamase (ESBL), designated CTX-M-55, among 7 patients who had infection with ESBL-producing Escherichia coli or Klebsiella pneumoniae at a university hospital in Thailand. The CTX-M-55 ESBL showed reduced susceptibility to ceftazidime. This investigation provides the relevant clinical and molecular epidemiology for the gene encoding for CTX-M-55 in the isolates from these patients.

摘要

我们报告了一种新型的超广谱β-内酰胺酶(ESBL),即CTX-M型,命名为CTX-M-55,该酶来自泰国一家大学医院7例感染产ESBL大肠埃希菌或肺炎克雷伯菌的患者。CTX-M-55 ESBL对头孢他啶的敏感性降低。本研究为这些患者分离株中编码CTX-M-55的基因提供了相关的临床和分子流行病学信息。

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