Beck Melinda A
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599-7461, USA.
J Nutr. 2007 May;137(5):1338-40. doi: 10.1093/jn/137.5.1338.
Selenium (Se), an essential trace element, and vitamin E, a lipid soluble antioxidant, are important mediators for protection against oxidative stress. Recent work has demonstrated that deficiencies in either Se or vitamin E result in increased viral pathogenicity and altered immune responses. Furthermore, deficiencies in either Se or vitamin E results in specific viral mutations, changing relatively benign viruses into virulent ones. Thus, host nutritional status should be considered a driving force for the emergence of new viral strains or newly pathogenic strains of known viruses.
硒（Se）是一种必需的微量元素，维生素E是一种脂溶性抗氧化剂，它们是抵御氧化应激的重要介质。最近的研究表明，硒或维生素E的缺乏都会导致病毒致病性增加和免疫反应改变。此外，硒或维生素E的缺乏会导致特定的病毒突变，将相对良性的病毒转变为毒性更强的病毒。因此，宿主的营养状况应被视为新病毒株或已知病毒新致病株出现的一个驱动因素。
