Matsumoto Madoka, Matsumoto Kenji, Abe Hiroshi, Tanaka Keiji
Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Nat Neurosci. 2007 May;10(5):647-56. doi: 10.1038/nn1890. Epub 2007 Apr 22.
To adapt behavior to a changing environment, one must monitor outcomes of executed actions and adjust subsequent actions accordingly. Involvement of the medial frontal cortex in performance monitoring has been suggested, but little is known about neural processes that link performance monitoring to performance adjustment. Here, we recorded from neurons in the medial prefrontal cortex of monkeys learning arbitrary action-outcome contingencies. Some cells preferentially responded to positive visual feedback stimuli and others to negative feedback stimuli. The magnitude of responses to positive feedback stimuli decreased over the course of behavioral adaptation, in correlation with decreases in the amount of prediction error of action values. Therefore, these responses in medial prefrontal cells may signal the direction and amount of error in prediction of values of executed actions to specify the adjustment in subsequent action selections.
为使行为适应不断变化的环境，人们必须监测已执行动作的结果，并据此调整后续动作。内侧前额叶皮层参与了绩效监测，但对于将绩效监测与绩效调整联系起来的神经过程却知之甚少。在此，我们记录了猴子内侧前额叶皮层中学习任意动作-结果关联的神经元活动。一些细胞对正向视觉反馈刺激有优先反应，而另一些细胞则对负向反馈刺激有反应。在行为适应过程中，对正向反馈刺激的反应幅度下降，这与动作值预测误差量的减少相关。因此，内侧前额叶细胞的这些反应可能会为已执行动作的值的预测误差的方向和量发出信号，以确定后续动作选择中的调整。
