干细胞微环境：跨物种的摇篮曲

Stem-cell niches: nursery rhymes across kingdoms.

作者信息

Scheres Ben

机构信息

Molecular Genetics Group, Department of Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, the Netherlands.

出版信息

Nat Rev Mol Cell Biol. 2007 May;8(5):345-54. doi: 10.1038/nrm2164.

DOI:10.1038/nrm2164

PMID:17450175

Abstract

Despite the large evolutionary distance between the plant and animal kingdoms, stem cells in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell-specification factors have been recruited from plant-specific gene families, maintenance factors that repress stem-cell differentiation are conserved between plants and animals. Recent evidence indicates that stem cells in multicellular organisms can be specified by kingdom-specific patterning mechanisms that connect to a related core of epigenetic stem-cell factors.

摘要

尽管植物界和动物界在进化上距离遥远，但两者的干细胞都存在于被称为干细胞微环境的特殊细胞环境中。虽然干细胞特化因子是从植物特有的基因家族中招募而来的，但抑制干细胞分化的维持因子在植物和动物之间是保守的。最近的证据表明，多细胞生物中的干细胞可以由与表观遗传干细胞因子的相关核心相连接的界别特异性模式机制来特化。