Djanashvili Kristina, Peters Joop A
Laboratory of Biocatalysis and Organic Chemistry, Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands.
Contrast Media Mol Imaging. 2007 Mar-Apr;2(2):67-71. doi: 10.1002/cmmi.132.
Lanthanide(III) complexes of polyaminocarboxylates are widely used in MRI as contrast agents. The paramagnetic properties of the metal ion contribute to the increase of (1)H relaxation rates, while the chelate offers a stable binding with the metal. The number of water molecules, coordinated directly to the Ln(III) ion, is very important for the relaxivity and, thus, the efficacy of these contrast agents. Here, we describe convenient methods to determine this parameter by measurement of Ln(III)-induced shifts of the water (17)O NMR resonance.
多氨基羧酸盐的镧系元素（III）配合物作为造影剂在磁共振成像中被广泛使用。金属离子的顺磁性质有助于提高（1）H弛豫率，而螯合物能与金属形成稳定的结合。直接与Ln（III）离子配位的水分子数量对于弛豫率以及这些造影剂的功效非常重要。在此，我们描述了通过测量Ln（III）诱导的水（17）O核磁共振共振位移来确定该参数的简便方法。
