Pekar J, Ligeti L, Ruttner Z, Lyon R C, Sinnwell T M, van Gelderen P, Fiat D, Moonen C T, McLaughlin A C
In Vivo NMR Research Center, National Institutes of Health, Bethesda, Maryland 20892.
Magn Reson Med. 1991 Oct;21(2):313-9. doi: 10.1002/mrm.1910210217.
We used 17O NMR imaging techniques to measure the H2(17)O concentration in a 0.8-ml voxel in the cat brain following injection of an arterial bolus of enriched H2(17)O and during inhalation of enriched 17O2. We also measured the H2(17)O concentration in arterial blood during 17O2 inhalation. The data from the first measurement were used to calculate the blood flow in the voxel. The data from all three measurements were combined to calculate the oxygen consumption in the voxel. The values of cerebral blood flow and oxygen consumption calculated with 17O NMR techniques agree reasonably well with values calculated for a similar region of the cat brain using autoradiographic techniques.
我们使用¹⁷O核磁共振成像技术，在向猫脑动脉团注富含H₂¹⁷O后以及吸入富含¹⁷O₂的过程中，测量了猫脑一个0.8毫升体素内的H₂¹⁷O浓度。我们还测量了吸入¹⁷O₂期间动脉血中的H₂¹⁷O浓度。第一次测量的数据用于计算体素内的血流量。将所有三次测量的数据结合起来计算体素内的氧耗量。用¹⁷O核磁共振技术计算出的脑血流量和氧耗量值，与使用放射自显影技术为猫脑类似区域计算出的值相当吻合。
