Arai T, Mori K, Nakao S, Watanabe K, Kito K, Aoki M, Mori H, Morikawa S, Inubushi T
Department of Anesthesia, Kyoto University Hospital, Japan.
Biochem Biophys Res Commun. 1991 Sep 16;179(2):954-61. doi: 10.1016/0006-291x(91)91911-u.
To explore the feasibility of in vivo 17O NMR for the estimation of cerebral blood flow and oxygen consumption, in vivo 17O NMR spectroscopy and imaging were employed in animal models. In the spectroscopy, the changes in the 17O NMR signal intensity after the injection of H2(17)O and the inhalation of 17O2 gas were obtained every 4 seconds with sufficient signal-to-noise ratios for the quantification of cerebral blood flow and oxygen consumption. In the imaging, although the time and spatial resolutions were insufficient for the quantification of H2(17)O, 17O NMR images of rabbit brain could be obtained, indicating that it is possible to map cerebral blood flow and oxygen consumption by 17O NMR imaging.
为探讨体内17O核磁共振用于估算脑血流量和氧耗量的可行性，在动物模型中采用了体内17O核磁共振波谱法和成像技术。在波谱分析中，每隔4秒获取注射H2(17)O和吸入17O2气体后17O核磁共振信号强度的变化情况，其信噪比足以用于定量脑血流量和氧耗量。在成像方面，尽管时间和空间分辨率不足以对H2(17)O进行定量分析，但仍可获得兔脑的17O核磁共振图像，这表明通过17O核磁共振成像来绘制脑血流量和氧耗量图是可行的。
