[Determination of the immune potency of lymphocyte-promoting factor (LPF) and filamentous hemagglutinin (FHA) molecules by intranasal challenge in mice].

All mice immunized with toxoid LPF and FHA molecules were found to be protected against infections by intranasal instillation of Bordetella pertussis. While a significant weight loss was observed in control mice within ten days following challenge, immunized mice were found to gain weight. Mice immunized with 20 micrograms doses of toxoid LPF were found to be also protected against intracerebral infection. FHA did not protect mice against such an infection.