Voon Wen-Chol, Su Ho-Ming, Yen Hsueh-Wei, Lin Tsung-Hsien, Lai Wen-Ter, Sheu Sheng-Hsiung
Division of Cardiology, Department of Internal Medicine, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ultrasound Med Biol. 2007 Jul;33(7):1098-103. doi: 10.1016/j.ultrasmedbio.2007.01.010. Epub 2007 Apr 23.
To test the applicability of isovolumic relaxation flow propagation velocity (IRFPV) as an indicator of relaxation, 38 patients undergoing cardiac catheterization for chest pain were included. The time constant of isovolumic left ventricular (LV) pressure decline (tau) had a significant correlation with the LV end-diastolic pressure, the peak negative dp/dt, the LV end-diastolic dimension, the fractional shortening, the late diastolic transmitral flow velocity, the early and late diastolic mitral annular velocities, the rapid filling flow propagation velocity, and the natural logarithms of heart rate, ejection fraction, LV end-systolic dimension and IRFPV (r = -0.773, p < 0.001). IRFPV was selected as the major independent determinant of tau, explaining 46% of its variance. In prediction of tau > or =42 ms, the sensitivity and specificity were 100% and 83% for IRFPV < or =104 cm/s, 77% and 67% for the rapid filling flow propagation velocity < or =50 cm/s, and 58% and 67% for the early diastolic mitral annular velocity < or =8 cm/s, respectively. In conclusion, our data suggest that IRFPV could be a better marker of LV relaxation than other parameters, as the rapid filling flow propagation velocity or the early diastolic mitral annular velocity.
为了测试等容舒张期血流传播速度（IRFPV）作为舒张功能指标的适用性，纳入了38例因胸痛接受心脏导管检查的患者。左心室（LV）等容压力下降的时间常数（tau）与LV舒张末期压力、最大负向dp/dt、LV舒张末期内径、缩短分数、舒张晚期二尖瓣血流速度、舒张早期和晚期二尖瓣环速度、快速充盈期血流传播速度以及心率、射血分数、LV收缩末期内径和IRFPV的自然对数显著相关（r = -0.773，p < 0.001）。IRFPV被选为tau的主要独立决定因素，解释了其46%的变异性。在预测tau≥42 ms时，对于IRFPV≤104 cm/s，敏感性和特异性分别为100%和83%；对于快速充盈期血流传播速度≤50 cm/s，敏感性和特异性分别为77%和67%；对于舒张早期二尖瓣环速度≤8 cm/s，敏感性和特异性分别为58%和67%。总之，我们的数据表明，与快速充盈期血流传播速度或舒张早期二尖瓣环速度等其他参数相比，IRFPV可能是LV舒张功能更好的标志物。
