Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2010 Oct;26(10):540-7. doi: 10.1016/S1607-551X(10)70083-8.
Mitral regurgitation (MR) can affect left ventricular diastolic parameters because of interference with regurgitation flow. This study compared left ventricular diastolic parameters between patients with and without significant MR. The MR group included 57 consecutive patients with significant MR. Fifty-seven age-, sex- and Tei index-matched patients without significant MR were selected as the reference group. Baseline characteristics and Tei index and its components were comparable between the MR and reference groups. The MR group had higher left atrial volume index, transmitral E wave velocity (E), ratio of E to transmitral A wave velocity, early diastolic mitral annular velocity (Ea), E/Ea, and ratio of E to isovolumic relaxation flow propagation velocity (IRFPV) (p ≤ 0.025), and lower E-wave deceleration time (p = 0.019) and late diastolic mitral annular velocity (p < 0.001). However, the two groups had similar IRFPV (p = 0.844). In conclusion, MR apparently affects E and Ea, but not IRFPV. IRFPV could potentially be a reliable relaxation parameter in patients with significant MR, but further confirmation by invasive studies is needed.
二尖瓣反流 (MR) 可因反流流量干扰而影响左心室舒张参数。本研究比较了有和无显著 MR 的患者的左心室舒张参数。MR 组包括 57 例连续的有显著 MR 的患者。选择 57 例年龄、性别和 Tei 指数匹配的无显著 MR 的患者作为参考组。MR 组和参考组的基线特征和 Tei 指数及其组成部分具有可比性。MR 组的左心房容积指数、二尖瓣口血流 E 波速度 (E)、E 与二尖瓣口血流 A 波速度的比值、二尖瓣环早期舒张速度 (Ea)、E/Ea 和 E 与等容舒张期血流传播速度 (IRFPV) 的比值较高 (p ≤ 0.025)，E 波减速时间和二尖瓣环晚期舒张速度较低 (p = 0.019 和 p < 0.001)。然而，两组的 IRFPV 相似 (p = 0.844)。总之，MR 明显影响 E 和 Ea，但不影响 IRFPV。IRFPV 可能是有显著 MR 的患者可靠的舒张参数，但需要进一步的有创研究来证实。
