Tate Mallory K, Lawrence William S, Gourley Randy L, Zavala Diana L, Weaver Lori E, Moen Scott T, Peterson Johnny W
Galveston National Laboratory, University of Texas Medical Branch, Galveston, Texas, USA.
BMC Res Notes. 2011 Sep 5;4:320. doi: 10.1186/1756-0500-4-320.
Heart failure is a critical condition that affects many people and often results from left ventricular dysfunction. Numerous studies investigating this condition have been performed using various model systems. To do so, investigators must be able to accurately measure myocardial performance in order to determine the degree of left ventricular function. In this model development study, we employ a wireless telemetry system purchased from Data Sciences International to continuously assess left ventricular function in the rabbit model.
We surgically implanted pressure-sensitive catheters fitted to wireless radio-transmitters into the left ventricle of Dutch-belted rabbits. Following recovery of the animals, we continuously recorded indices of cardiac contractility and ventricular relaxation at baseline for a given time period. The telemetry system allowed us to continuously record baseline left ventricular parameters for the entire recording period. During this time, the animals were unrestrained and fully conscious. The values we recorded are similar to those obtained using other reported methods.
The wireless telemetry system can continuously measure left ventricular pressure, cardiac contractility, and cardiac relaxation in the rabbit model. These results, which were obtained just as baseline levels, substantiate the need for further validation in this model system of left ventricular assessment.
心力衰竭是一种影响众多人群的严重病症，通常由左心室功能障碍引起。已经使用各种模型系统对这种病症进行了大量研究。为此，研究人员必须能够准确测量心肌性能，以便确定左心室功能的程度。在这项模型开发研究中，我们使用从数据科学国际公司购买的无线遥测系统，在兔模型中持续评估左心室功能。
我们通过手术将安装有无线无线电发射器的压敏导管植入荷兰带兔的左心室。动物恢复后，我们在给定时间段内持续记录基线时的心脏收缩力和心室舒张指标。遥测系统使我们能够在整个记录期间持续记录基线左心室参数。在此期间，动物不受约束且完全清醒。我们记录的值与使用其他报道方法获得的值相似。
无线遥测系统可以在兔模型中持续测量左心室压力、心脏收缩力和心脏舒张。这些作为基线水平获得的结果证实了在该左心室评估模型系统中进行进一步验证的必要性。
