Bauer K, Lorenz R J, Wittmann G
Arch Virol. 1975;49(4):349-57. doi: 10.1007/BF01318244.
The statistical relationship between the titers of neutralizing antibodies and the immunity of 706 pigs vaccinated against FMD was studied. This was done for each of four virus strains separately. Whereas no correlation between both test systems could be detected in case of the strains A5 Westerwald, C Detmold and O1Santander, a significant correlation was ascertained for the strain O1Kaufbeuren. Becuase of the different findings depending on the virus strain under study it was concluded that the antibody titer alone does not provide a useful measure for potency testing of FMD-vaccines for pigs.
研究了706头接种口蹄疫疫苗的猪的中和抗体效价与免疫力之间的统计关系。对四种病毒株分别进行了此项研究。在A5韦斯特瓦尔德株、C代特莫尔德株和O1桑坦德株的情况下,未检测到两种检测系统之间的相关性,但对于O1考夫博伊伦株,确定存在显著相关性。由于根据所研究的病毒株有不同的结果,得出结论:仅抗体效价不能为猪口蹄疫疫苗的效力测试提供有用的衡量标准。