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[猪口蹄疫疫苗接种后免疫力与中和抗体水平关系的研究（作者译）]

[Studies on the Relationship between immunity and the level of neutralizing antibodies in pigs vaccinated against foot-and-mouth disease (author's transl)].

作者信息

Bauer K, Lorenz R J, Wittmann G

出版信息

Arch Virol. 1975;49(4):349-57. doi: 10.1007/BF01318244.

DOI:10.1007/BF01318244
PMID:174529
Abstract

The statistical relationship between the titers of neutralizing antibodies and the immunity of 706 pigs vaccinated against FMD was studied. This was done for each of four virus strains separately. Whereas no correlation between both test systems could be detected in case of the strains A5 Westerwald, C Detmold and O1Santander, a significant correlation was ascertained for the strain O1Kaufbeuren. Becuase of the different findings depending on the virus strain under study it was concluded that the antibody titer alone does not provide a useful measure for potency testing of FMD-vaccines for pigs.

摘要

研究了706头接种口蹄疫疫苗的猪的中和抗体效价与免疫力之间的统计关系。对四种病毒株分别进行了此项研究。在A5韦斯特瓦尔德株、C代特莫尔德株和O1桑坦德株的情况下，未检测到两种检测系统之间的相关性，但对于O1考夫博伊伦株，确定存在显著相关性。由于根据所研究的病毒株有不同的结果，得出结论：仅抗体效价不能为猪口蹄疫疫苗的效力测试提供有用的衡量标准。

相似文献

1
[Studies on the Relationship between immunity and the level of neutralizing antibodies in pigs vaccinated against foot-and-mouth disease (author's transl)].[猪口蹄疫疫苗接种后免疫力与中和抗体水平关系的研究（作者译）]
Arch Virol. 1975;49(4):349-57. doi: 10.1007/BF01318244.
2
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The challenge of vaccinated pigs with foot-and-mouth disease virus.用口蹄疫病毒对已接种疫苗的猪进行攻毒试验的挑战。
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[Testing of the activity of anti-foot-and-mouth disease vaccines].
Dev Biol Stand. 1976;35:243-70.

引用本文的文献

1
Enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. III. Evaluation of antibodies after infection and vaccination.用于检测口蹄疫病毒抗体的酶联免疫吸附测定（ELISA）。III. 感染和接种疫苗后抗体的评估。
Epidemiol Infect. 1987 Dec;99(3):733-44. doi: 10.1017/s0950268800066590.

本文引用的文献

1
[Vaccination of pigs with a DEAE dextran containing bivalent foot and mouth disease vaccine].
Berl Munch Tierarztl Wochenschr. 1974 May;87(9):170-3.
2
[Trials of immunization of swine against foot-and-mouth disease using EEI-DEAE-Dextran vaccines].[使用EEI-DEAE-葡聚糖疫苗对猪进行口蹄疫免疫试验]
Bull Off Int Epizoot. 1972 May-Jun;77(5):875-85.
3
Experiments on vaccination of pigs with ethyl-ethyleneimine (EEI) diethylaminoethyl dextran (DEAE-D) foot-and-mouth disease vaccines. Influence of route of inoculation and dose of antigen on the duration of immunity.用乙撑亚胺（EEI）二乙氨基乙基葡聚糖（DEAE-D）口蹄疫疫苗对猪进行接种的实验。接种途径和抗原剂量对免疫持续时间的影响。
Arch Gesamte Virusforsch. 1972;36(3):251-64. doi: 10.1007/BF01249856.
4
[Attempted vaccination of swine with inactive aphthous virus vaccines. I. Tests of O virus inactivated with hydroxylamine, formol, heat and pH].
Bull Off Int Epizoot. 1969 Mar-Apr;71(3-4):351-79.