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本文引用的文献

1
[Relation between the titer of neutralizing antibodies and the protection of animals following anti-aphthous vaccination].[抗口蹄疫疫苗接种后中和抗体效价与动物保护作用之间的关系]
Ann Inst Pasteur (Paris). 1962 Aug;103:252-61.
2
The relationship between serum antibody titres and protection from foot and mouth disease in pigs after oil emulsion vaccination.
J Biol Stand. 1984 Oct;12(4):379-89. doi: 10.1016/s0092-1157(84)80062-1.
3
A new enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. II. Application.一种用于检测口蹄疫病毒抗体的新型酶联免疫吸附测定法（ELISA）。II. 应用
J Immunol Methods. 1986 Oct 23;93(1):123-9. doi: 10.1016/0022-1759(86)90442-4.
4
A new enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. I. Development and method of ELISA.一种用于检测口蹄疫病毒抗体的新型酶联免疫吸附测定法（ELISA）。I. ELISA的开发与方法。
J Immunol Methods. 1986 Oct 23;93(1):115-21. doi: 10.1016/0022-1759(86)90441-2.
5
Protection of cattle against foot-and-mouth disease by a synthetic peptide.一种合成肽对牛口蹄疫的防护作用。
Science. 1986 May 2;232(4750):639-41. doi: 10.1126/science.3008333.
6
Radial immuno-diffusion and serum-neutralisation techniques for the assay of antibodies to swine vesicular disease.
Res Vet Sci. 1976 Mar;20(2):142-7.
7
[Studies on the Relationship between immunity and the level of neutralizing antibodies in pigs vaccinated against foot-and-mouth disease (author's transl)].[猪口蹄疫疫苗接种后免疫力与中和抗体水平关系的研究（作者译）]
Arch Virol. 1975;49(4):349-57. doi: 10.1007/BF01318244.

用于检测口蹄疫病毒抗体的酶联免疫吸附测定（ELISA）。III. 感染和接种疫苗后抗体的评估。

Enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. III. Evaluation of antibodies after infection and vaccination.

作者信息

Hamblin C, Kitching R P, Donaldson A I, Crowther J R, Barnett I T

机构信息

Department of Virus Diagnosis, Pirbright Laboratory, Woking, Surrey.

出版信息

Epidemiol Infect. 1987 Dec;99(3):733-44. doi: 10.1017/s0950268800066590.

DOI:10.1017/s0950268800066590
PMID:3428376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2249258/
Abstract

Investigations using a liquid-phase blocking sandwich enzyme-linked immunosorbent assay (ELISA) for the measurement of antibodies against foot-and-mouth disease virus (FMDV) in sera from sheep and from cattle are reported, and results compared with those obtained by virus neutralization (VN) tests. Serum antibody titres in sheep after primary vaccination and in cattle challenged with a natural aerosol after vaccination were similar by ELISA and VN. However, the antibody levels detected in sera of cattle during early infection and of vaccinated cattle after intradermolingual challenge were clearly greater by ELISA than by VN. The ELISA titres in cattle sera following synthetic peptide vaccination indicated some relationship to protection and were clearly different from those recorded by VN. On the other hand, the antibody levels following conventional vaccination showed that ELISA and VN titres in cattle sera were related to protection. Although there was a good agreement between the ELISA antibody titre and protection for the four vaccines used, by VN the titre which afforded protection varied depending on the vaccine used. The ELISA was considered therefore to be more reliable than the VN and may prove useful for evaluating the immunological response of animals following infection and following vaccination.

摘要

报告了使用液相阻断夹心酶联免疫吸附测定（ELISA）检测绵羊和牛血清中口蹄疫病毒（FMDV）抗体的研究，并将结果与病毒中和（VN）试验所得结果进行了比较。通过ELISA和VN检测，初次接种疫苗后绵羊以及接种疫苗后经自然气溶胶攻击的牛的血清抗体滴度相似。然而，在早期感染的牛血清以及皮内舌接种攻击后接种疫苗的牛血清中，ELISA检测到的抗体水平明显高于VN检测结果。合成肽疫苗接种后牛血清中的ELISA滴度表明其与保护作用存在一定关系，且与VN记录的结果明显不同。另一方面，传统疫苗接种后的抗体水平显示，牛血清中的ELISA和VN滴度与保护作用相关。尽管所使用的四种疫苗的ELISA抗体滴度与保护作用之间有良好的一致性，但通过VN检测，提供保护作用的滴度因所用疫苗而异。因此，ELISA被认为比VN更可靠，可能有助于评估动物感染和接种疫苗后的免疫反应。