Chappuis G, Brun A, Roulet C, Favre H, Terré J
Dev Biol Stand. 1976;35:139-48.
A certain number of parameters involved in the manufacture, control and use of an efficacious vaccine against foot-and-mouth disease have been studied. This report considers the problems raised by the standardization of the raw material constituent to the vaccine as well as the different types of innocuity and activity testing carried out on sows, young pigs and bacon pigs. Special attention is given to virulence testing methods, to the criteria allowing evaluation of the quality of the vaccines and to the transmission of maternal immunity of the sows to their piglets and its incidence on the vaccination schedule.
对制造、控制和使用有效的口蹄疫疫苗所涉及的若干参数进行了研究。本报告考虑了疫苗原材料成分标准化所引发的问题,以及对母猪、幼猪和育肥猪进行的不同类型的无害性和活性测试。特别关注毒力测试方法、评估疫苗质量的标准,以及母猪的母源免疫力向仔猪的传递及其对疫苗接种计划的影响。